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Parikh, Palakben K.
- Plagiarism:A Serious Malpractice in Latest Infrastructure through Webhunting
Authors
1 Department of Pharma Chemistry, Shri Sarvajanik Pharmacy College, Gujarat Technological University, Arvind Baug, Mehsana-384001, Gujarat,, IN
2 Department of Pharmaceutical Chemistry, Shri Sarvajanik Pharmacy College, Gujarat Technological University, Arvind Baug, Mehsana-384001, Gujarat, IN
Source
Research Journal of Science and Technology, Vol 2, No 6 (2010), Pagination: 134-144Abstract
Modern wired generation has a serious hobby in webhunting through netsurfing cum browsing. Huge data collection on various topics and further reformatting to present in desired platform is a new style between new generations to old generation generates the coinage malpractice of plagiarism. Strategies of Select-Copy-Paste are the three muskatieers to build a new entity which is an assembled chapter on new pages of presentable format of new article engineered by manipulated fabrication under the umbrella of malpractice. Some detectors have been launched to control over this malpractice by latest software.
- Structure Activity Relationship Studies of Substituted Mannich Bases of Pyrazolo [1, 2-A][1,2,4,6]-Tetrazepine-3,7-Dione Ring System with Variable Electronegative Atoms (Urea/Thiourea/Guanidine) for Antimicrobial and Antifungal Activity
Authors
1 Department of Pharmaceutical Chemistry, Shri Sarvajanik Pharmacy College, Gujarat Technological University, Arvind Baug, Mehsana-384001, Gujarat, IN
Source
Asian Journal of Research in Chemistry, Vol 4, No 5 (2011), Pagination: 838-844Abstract
9-methyl-1,5-diphenyl-3H,7H-pyrazolo-[1,2-a][1,2,4,6]-tetrazepine-3,7-dione ring system has been synthesised by the reaction between hydrazine and ethyl acetoacetate produced pyrazolone moiety which on benzoylation produced dibenzoyl derivative which on condensation with urea produced 9-methyl-1,5-diphenyl-3H,7H- pyrazolo-[1,2-a][1,2,4,6]-tetrazepine-3,7-dione ring which on alkaline oxidation with KMnO4/KOH produced carboxylic moiety. Treatment with thionyl chloride of produced acid chloride derivative. This on condensation with Mannich base produced by benzaldehyde with urea/thiourea/guanidine produced the desired moiety.
The synthesised compounds were characterised by N% and spectral datas and antimicrobial and antifungal screening has been performed by zone of inhibition studies and MIC calculation with standard antibiotic/antifungal drug against (gram+ve) and (gram-ve) bacterial and fungal strains on agar media after 24 hours incubation at 37ۧC for antimicrobial activity and 24°C for antifungal activity. Gram positive: Staphylococcus aureus ATCC 9144, Bacillus subtilis ATCC 6633, Gram negative: Escherichia coli ATCC 25922, Fungal strain: Candida albicans ATCC 10231 It has been observed that the Compound-2 (X=S) showed maximum antibacterial activity against Escherichia coli, Compound-1 (X=O) and against Bacillus subtilis and Compound-1 (X=O) and against Staphylococcus aureus. Oxygen and Sulphur has two lone pairs whereas Nitrogen has one lone pair of electrons but the electronegativity of Oxygen (X=O; 3.5), electronegativity of Sulphur (X=S; 2.4) and electronegativity of Nitrogen (X=N+H; 3.1+2.2=5.3). MIC value of all the compounds have been found as 250μg as Minimum Inhibitory Concentration by serial dilution method and MIC of Cloxacillin is 250μg and for Fluconazole is 5.5μg.
Keywords
Pyrazolo-Tetrazepine, Antibacterial, Antifungal, Benzoylation.- 10-15≈FEMTOChemistry:New Frontier Exponent after NANOChemistry
Authors
1 Department of Pharmaceutical Chemistry, Shri Sarvajanik Pharmacy College, Gujarat Technological University, Arvind Baug, Mehsana-384001, Gujarat, IN